Vacancy PhD

Vacancy - PhD

During pregnancy, the maternal immune system adapts to tolerate the fetus. Insufficient tolerance is linked to preeclampsia, an inflammatory condition affecting 5-10% of pregnancies, leading to maternal and neonatal mortality and morbidity. Preeclampsia is often diagnosed late, usually resorting to early delivery with frequently detrimental consequences for the fetus.

Early prediction of preeclampsia is hard due to the absence of clear symptoms and lack of reliable early biomarkers for disbalances in the T-cell populations. To address this, this project aims to create a robust prognostic test. This test will quantitatively measure the maternal inflammatory response to paternal Major Histocompatibility Complex (MHC) molecules early in pregnancy due to T-cell disbalances, which together with the T cell fitness is a predictor for complicated pregnancy such as preeclampsia.